Understanding the link between Alzheimer's disease and Diabetes Mellitus in the choroid plexus – an in-vitro study
Téma dosud nemá řešitele. Máš-li o něj zájem, zaregistruj se a přihlaš se k tématu.- Instituce
- Masarykova univerzita
- Fakulta/ústav
- Fakulta lékařská
- Další údaje o pracovišti
- Anatomický ústav
- Lektoři
- Petra Orviská
Introduction:
Alzheimer’s disease (AD) is a devastating condition that leads to memory loss, cognitive decline, and ultimately death. Recent studies suggest that the choroid plexus (CP), a structure found in all of the brain’s ventricles, plays a crucial role in clearing toxic amyloid-beta (Aβ42), a key factor in AD pathogenesis. Interestingly, type 2 diabetes mellitus (DM) is emerging as a major risk factor associated with AD, as both conditions share important mechanisms such as insulin resistance, inflammation, and metabolic dysfunction. Latest research suggests that the CP may be involved in brain insulin regulation, further linking diabetes to neurodegeneration. Understanding how the CP contributes to AD and its connection to metabolic disorders could open new doors for treatment strategies. This project aims to explore this link using an in vitro cell culture model of choroidal epithelial cells Z310, which wil be treated with Aβ42 peptide to induce the AD phenotype. The changes in Insulin receptor will be studied using Immunocytochemistry.
Supervisor: Mgr. Petra Orviská
References:
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Jeong, SH. et al. Choroid Plexus Volume, Amyloid Burden, and Cognition in the Alzheimer's Disease Continuum. Aging Dis. 2024 Jan 23. doi: 10.14336/AD.2024.0118. Epub ahead of print. PMID: 38300638.
Chavda, V. et al. Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells. Brain Sci. 2024 Mar 15;14(3):284. doi: 10.3390/brainsci14030284. PMID: 38539672; PMCID: PMC10969071.
Milstein, JL., Ferris, HA. The brain as an insulin-sensitive metabolic organ. Mol Metab. 2021 Oct;52:101234. doi: 10.1016/j.molmet.2021.101234. Epub 2021 Apr 15. PMID: 33845179; PMCID: PMC8513144.