In vitro study of changes in blood-cerebrospinal fluid barrier after chemotherapy
Téma již má řešitele.- Řešitel
- Vojtěch Vlček - Gymnázium Brno, Slovanské náměstí, příspěvková organizace
- Instituce
- Masarykova univerzita
- Fakulta/ústav
- Fakulta lékařská
- Další údaje o pracovišti
- Anatomy Deprtmnet
- Lektoři
- Alemeh Zamani
- Podpora
- JCMM podpořila toto SOČ téma částkou 20 000 Kč na materiál a částkou 10 000 Kč na honorář školitele.
Cancer treatment, specifically chemotherapy, has revolutionized the landscape of oncology, offering new hope and improved survival rates for patients. However, neuropathic pain, one of the major side effects of chemotherapy, has been described as a limitation of the treatment. Consequently, the potential impact of chemotherapy agents on the intricate barriers protecting the brain, such as the blood-cerebrospinal fluid (CSF) barrier, remains unclear. The blood-CSF barrier, a dynamic interface crucial for maintaining central nervous system homeostasis, plays a pivotal role in safeguarding the delicate balance of the brain's microenvironment.
This study proposes an in vitro investigation to unravel the intricacies of chemotherapy-induced alterations in the blood-CSF barrier using techniques such as cell culture, immunocytochemistry, and Western blot analysis.