Advances and opportunities of natural molecules for drug discovery in Czech Republic
Téma dosud nemá řešitele. Máš-li o něj zájem, zaregistruj se a přihlaš se k tématu.- Instituce
- Vysoké učení technické v Brně
- Fakulta/ústav
- Fakulta elektrotechniky a komunikačních technologií
- Další údaje o pracovišti
- Department of Biomedical Engineering
- Lektoři
- Sudeep Roy
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases [1-3].
The project involves investigation of natural molecules obtained from medicinal and aromatic plants through Cheminformatics approaches.
The student will screen diverse natural phytomolecules from specialized libraries through virtual screening and molecular docking. The study, aims to search potent diverse molecules to understand the mechanism of the protein-drug interactions in the treatment of diseases caused, mainly in the Czech Republic.
References:
1. Waltenberger, B., Mocan, A., Šmejkal, K., Heiss, EHEH & Atanasov, AAGAG Natural products to counteract the epidemic of cardiovascular and metabolic disorders. Molecules 21, 807 (2016).
2. Li, JW-H. & Vederas, JC Drug discovery and natural products: end of an era or an endless frontier? Science 325, 161–165 (2009).
3. Corson, TW & Crews, CM Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell 130, 769–774 (2007).