Supervisors

Internship Project for high-school students- Spring 2023

 

Brain reaction to chemotherapy

Introduction

Paclitaxel is an effective chemotherapeutic agent and it can cause toxic effects on peripheral nerves, often leading to neuropathic pain. It remains unclear how the central nervous system responds to paclitaxel. 

Neuroinflammation of brain ventricles is an inherent host-defense mechanism to protect and restore the normal structure and function of the brain against infection and injury. In inflammation, macrophages have three major functions; antigen presentation, phagocytosis, and immunomodulation through the production of various cytokines and growth factors. Macrophages play a critical role in initiating, maintaining, and resolving inflammation.

However, the exact role of Macrophages in the spread of inflammation within the brain is unclear. Using an in vivo model, we aim to uncover the mechanisms by which inflammatory reactions spread in the brain.

     Supervisor: Parisa EmamiAref, M.Sc.

     A motivated student with English language skills

Experimental plan

Brain slices of the rat model of paclitaxel-induced neuropathic pain subjected to immunohistochemistry will be used for the study. 

 

 

 

 

 

 

 

 

 

 

Reference

 

1.?Solár P, Zamani A, Kubíčková L, Dubový P, Joukal M. Choroid plexus and the blood-cerebrospinal fluid barrier in disease. Fluids Barriers CNS. 2020 May 6;17(1):35.

2.?Wan Y, Hua Y, Garton HJL, Novakovic N, Keep RF, Xi G. Activation of epiplexus macrophages in hydrocephalus caused by subarachnoid hemorrhage and thrombin. CNS Neurosci Ther. 2019 Oct 21;25(10):1134–41.

3.?Joukal M, Klusáková I, Solár P, Kuklová A, Dubový P. Cellular reactions of the choroid plexus induced by peripheral nerve injury. Neurosci Lett. 2016 Aug 15;628:73–7.