Cellular Stress Induced by Amyloid-ß Aggregation in Choroid Plexus Epithelial Cells
Téma dosud nemá řešitele. Máš-li o něj zájem, zaregistruj se a přihlaš se k tématu.- Instituce
- Masarykova univerzita
- Fakulta/ústav
- Fakulta lékařská
- Další údaje o pracovišti
- Anatomy
- Lektoři
- Alemeh Zamani
Alzheimer’s disease (AD) is characterized by the accumulation and aggregation of amyloid-β (Aβ) peptides in the brain. The choroid plexus (CP), which forms the blood–cerebrospinal fluid barrier, plays an important role in maintaining brain homeostasis and in the clearance of Aβ from the cerebrospinal fluid. However, the direct effects of intracellular Aβ aggregation on choroid plexus epithelial cells remain insufficiently understood.
This project aims to investigate cellular stress responses induced by Aβ aggregation in rat choroid plexus epithelial cells (Z310 cell line). The study focuses on identifying changes in cellular signaling and stress-related pathways following Aβ exposure over both acute and prolonged time periods. By characterizing how Aβ aggregation affects choroid plexus epithelial cells, this study seeks to clarify whether CP dysfunction may contribute to impaired brain homeostasis in Alzheimer’s disease. Understanding these mechanisms may provide new insights into the role of the blood–CSF barrier in neurodegeneration and identify potential targets for future therapeutic strategies.